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Chemistry and pharmacology of anticancer drugs / David E. Thurston

Thurston, David E.
Material type: materialTypeLabelBook; Format: print Publisher: Boca Raton : CRC Press, 2006Description: 290 p. ; 25 cm.ISBN: 0-8493-9219-5.Subject(s): Farmacología | Química clínica | Química farmaceútica
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615.03/THU/che (Browse shelf) Available   Shelving location | Bibliomaps® BIBLIOG. RECOM. 374197128X
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Provides the authoritative insight of a respected scientist with 25 years of experience in cancer research and novel drug development. Covers the complete range of anticancer agents, both in clinical use and in the research and development stage, including biological agents. Details each agent's chemistry, mechanisms of action, spectrum of activity, and side effects. Presents chemical structures and generic and trade names of all chemotherapeutic agents in clinical use. Introduces cutting-edge research methodologies and tools. After reviewing the causes of cancer and the philosophy of drug discovery, Chemistry and Pharmacology of Anticancer Drugs surveys those clinically relevant families of anticancer agents (including biological agents) in use, as well as those currently being researched. The author discusses the history of each agent, and offers a detailed discussion of its chemistry, mechanism of action, spectrum of activity, side effects, and formulation issues in the context of structure and chemistry. Uniquely, this work details the full chemical structures of the agents, and when possible includes both generic and trade names. It also introduces new research tools and methodologies

Índice: Introduction. Terminology. Metastases. Causes of Cancer. Mechanisms of Genomic Damage. Treatment. Antimetabolites. DNA-interactive Compounds. Intercalating Agents. Antitubulin Agents. Signal Inhibition. Hormonal Therapies. Vascular Targeting Agents. Tumour Targeting Therapies. Biologicals. Miscellaneous Agents. The Future. Adjunct Therapies. Further Reading.

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