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The cell : a molecular approach / Geoffrey M. Cooper, Robert E. Hausman

Cooper, Geoffrey M.
Contributor(s): Hausman, Robert E.
Material type: materialTypeLabelBook; Format: print Publisher: Washington : Sinauer Associates, 2007Edition: 4th ed.Description: XIX, 820 p. : il. ; 29 cm.ISBN: 0-87893-219-4.Subject(s): Citología | Biología molecular
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Manuales (7 días) 02. BIBLIOTECA CAMPUS PUERTO REAL
576.3/COO/cel (Browse shelf)   Shelving location | Bibliomaps® PREST. LIBROS 3741979102

BIOLOGÍA MOLECULAR GRADO EN QUÍMICA Asignatura actualizada 2017-2018

Monografías 02. BIBLIOTECA CAMPUS PUERTO REAL
576.3/COO/cel (Browse shelf)   Shelving location | Bibliomaps® PREST. LIBROS 3741979111
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Enhanced descriptions from Syndetics:

The fourth edition has been thoroughly updated to reflect major advances in the field, including the role of microRNAs in the regulation of gene expression, advances in stem cell biology as well as Oncogenes and the rational design of new anticancer drugs.

Índice

Bibliografía: p. 763-765

The fourth edition of The Cell has been thoroughly updated to reflect major advances in the field including the role of microRNAs in the regulation of gene expression, advances in stem cell biology as well as oncogenes and the rational design of new anticancer drugs. While retaining the overall structure and pedagogy that made previous editions so successful, the fourth edition now includes additional chapters on Programmed Cell Death and the Maintenance of Adult Tissues. There is also significant new material on topics like Signaling Networks, Cell-Matrix Interactions and Bioinformations to keep The Cell fresh, vibrant and perpetually appealing to students.

Table of contents provided by Syndetics

  • Preface (p. xiv)
  • Organization and Features of The Cell (p. xvi)
  • Media and Supplements to Accompany The Cell (p. xviii)
  • Part I Introduction
  • 1 An Overview of Cells and Cell Research (p. 3)
  • The Origin and Evolution of Cells (p. 4)
  • The First Cell (p. 4)
  • The Evolution of Metabolism (p. 7)
  • Present-Day Prokaryotes (p. 8)
  • Eukaryotic Cells (p. 9)
  • The Origin of Eukaryotes (p. 10)
  • The Development of Multicellular Organisms (p. 12)
  • Cells as Experimental Models (p. 16)
  • E. coli (p. 16)
  • Yeasts (p. 17)
  • Caenorhabditis elegans (p. 17)
  • Drosophila melanogaster (p. 18)
  • Arabidopsis thaliana (p. 19)
  • Vertebrates (p. 19)
  • Tools of Cell Biology (p. 21)
  • Light Microscopy (p. 21)
  • Electron Microscopy (p. 27)
  • Subcellular Fractionation (p. 30)
  • Growth of Animal Cells in Culture (p. 33)
  • Culture of Plant Cells (p. 36)
  • Viruses (p. 36)
  • Key Experiment: Animal Cell Culture (p. 35)
  • Molecular Medicine: Viruses and Cancer (p. 37)
  • Summary and Key Terms (p. 39)
  • Questions (p. 41)
  • References and Further Reading (p. 41)
  • 2 The Composition of Cells (p. 43)
  • The Molecules of Cells (p. 43)
  • Carbohydrates (p. 44)
  • Lipids (p. 46)
  • Nucleic Acids (p. 50)
  • Proteins (p. 52)
  • Cell Membranes (p. 58)
  • Membrane Lipids (p. 60)
  • Membrane Proteins (p. 61)
  • Transport across Cell Membranes (p. 63)
  • Proteomics: Large-Scale Analysis of Cell Proteins (p. 65)
  • Identification of Cell Proteins (p. 65)
  • Global Analysis of Protein Localization (p. 68)
  • Protein Interactions (p. 69)
  • Key Experiment: The Folding of Polypeptide Chains (p. 54)
  • Key Experiment: The Structure of Cell Membranes (p. 59)
  • Summary and Key Terms (p. 70)
  • Questions (p. 71)
  • References and Further Reading (p. 71)
  • 3 Cell Metabolism (p. 73)
  • The Central Role of Enzymes as Biological Catalysts (p. 73)
  • The Catalytic Activity of Enzymes (p. 73)
  • Mechanisms of Enzymatic Catalysis (p. 74)
  • Coenzymes (p. 78)
  • Regulation of Enzyme Activity (p. 79)
  • Metabolic Energy (p. 81)
  • Free Energy and ATP (p. 81)
  • The Generation of ATP from Glucose (p. 84)
  • The Derivation of Energy from Other Organic Molecules (p. 89)
  • Photosynthesis (p. 90)
  • The Biosynthesis of Cell Constituents (p. 91)
  • Carbohydrates (p. 92)
  • Lipids (p. 93)
  • Proteins (p. 94)
  • Nucleic Acids (p. 97)
  • Key Experiment: Antimetabolites and Chemotherapy (p. 98)
  • Molecular Medicine: Phenylketonuria (p. 96)
  • Summary and Key Terms (p. 100)
  • Questions (p. 101)
  • References and Further Reading (p. 101)
  • 4 Fundamentals of Molecular Biology (p. 103)
  • Heredity, Genes, and DNA (p. 103)
  • Genes and Chromosomes (p. 104)
  • Genes and Enzymes (p. 107)
  • Identification of DNA as the Genetic Material (p. 107)
  • The Structure of DNA (p. 108)
  • Replication of DNA (p. 110)
  • Expression of Genetic Information (p. 111)
  • Colinearity of Genes and Proteins (p. 111)
  • The Role of Messenger RNA (p. 112)
  • The Genetic Code (p. 113)
  • RNA Viruses and Reverse Transcription (p. 115)
  • Recombinant DNA (p. 118)
  • Restriction Endonucleases (p. 118)
  • Generation of Recombinant DNA Molecules (p. 121)
  • Vectors for Recombinant DNA (p. 122)
  • DNA Sequencing (p. 125)
  • Expression of Cloned Genes (p. 126)
  • Detection of Nucleic Acids and Proteins (p. 129)
  • Amplification of DNA by the Polymerase Chain Reaction (p. 129)
  • Nucleic Acid Hybridization (p. 131)
  • Antibodies as Probes for Proteins (p. 134)
  • Gene Function in Eukaryotes (p. 137)
  • Genetic Analysis in Yeasts (p. 137)
  • Gene Transfer in Plants and Animals (p. 139)
  • Mutagenesis of Cloned DNAs (p. 142)
  • Introducing Mutations into Cellular Genes (p. 142)
  • Interfering with Cellular Gene Expression (p. 145)
  • Key Experiment: The DNA Provirus Hypothesis (p. 116)
  • Molecular Medicine: HIV and AIDS (p. 120)
  • Summary and Key Terms (p. 147)
  • Questions (p. 149)
  • References and Further Reading (p. 150)
  • Part II The Flow of Genetic Information
  • 5 The Organization and Sequences of Cellular Genomes (p. 155)
  • The Complexity of Eukaryotic Genomes (p. 155)
  • Introns and Exons (p. 157)
  • Repetitive DNA Sequences (p. 161)
  • Gene Duplication and Pseudogenes (p. 164)
  • The Composition of Higher Eukaryotic Genomes (p. 165)
  • Chromosomes and Chromatin (p. 166)
  • Chromatin (p. 166)
  • Centromeres (p. 171)
  • Telomeres (p. 175)
  • The Sequences of Complete Genomes (p. 176)
  • Prokaryotic Genomes (p. 177)
  • The Yeast Genome (p. 178)
  • The Genomes of Caenorhabditis elegans and Drosophila melanogaster (p. 180)
  • Plant Genomes (p. 183)
  • The Human Genome (p. 185)
  • The Genomes of Other Vertebrates (p. 190)
  • Bioinformatics and Systems Biology (p. 192)
  • Systematic Screens of Gene Function (p. 193)
  • Regulation of Gene Expression (p. 194)
  • Variation among Individuals and Genomic Medicine (p. 195)
  • Key Experiment: The Discovery of Introns (p. 158)
  • Key Experiment: The Human Genome (p. 188)
  • Summary and Key Terms (p. 196)
  • Questions (p. 198)
  • References and Further Reading (p. 199)
  • 6 Replication, Maintenance, and Rearrangements of Genomic DNA (p. 201)
  • DNA Replication (p. 202)
  • DNA Polymerases (p. 202)
  • The Replication Fork (p. 202)
  • The Fidelity of Replication (p. 209)
  • Origins and the Initiation of Replication (p. 211)
  • Telomeres and Telomerase: Maintaining the Ends of Chromosomes (p. 214)
  • DNA Repair (p. 216)
  • Direct Reversal of DNA Damage (p. 216)
  • Excision Repair (p. 219)
  • Translesion DNA Synthesis (p. 223)
  • Recombinational Repair (p. 225)
  • Recombination between Homologous DNA Sequences (p. 227)
  • Models of Homologous Recombination (p. 228)
  • Enzymes Involved in Homologous Recombination (p. 229)
  • DNA Rearrangements (p. 233)
  • Site-Specific Recombination (p. 233)
  • Transposition via DNA Intermediates (p. 239)
  • Transposition via RNA Intermediates (p. 242)
  • Gene Amplification (p. 247)
  • Key Experiment: Rearrangement of Immunoglobulin Genes (p. 240)
  • Molecular Medicine: Colon Cancer and DNA Repair (p. 224)
  • Summary and Key Terms (p. 249)
  • Questions (p. 250)
  • References and Further Reading (p. 251)
  • 7 RNA Synthesis and Processing (p. 253)
  • Transcription in Prokaryotes (p. 254)
  • RNA Polymerase and Transcription (p. 254)
  • Repressors and Negative Control of Transcription (p. 258)
  • Positive Control of Transcription (p. 261)
  • Eukaryotic RNA Polymerases and General Transcription Factors (p. 262)
  • Eukaryotic RNA Polymerases (p. 262)
  • General Transcription Factors and Initiation of Transcription by RNA Polymerase II (p. 262)
  • Transcription by RNA Polymerases I and III (p. 266)
  • Regulation of Transcription in Eukaryotes (p. 268)
  • cis-Acting Regulatory Sequences: Promoters and Enhancers (p. 269)
  • Transcription Factor Binding Sites (p. 272)
  • Transcriptional Regulatory Proteins (p. 273)
  • Structure and Function of Transcriptional Activators (p. 277)
  • Eukaryotic Repressors (p. 280)
  • Relationship of Chromatin Structure to Transcription (p. 281)
  • Regulation of Transcription by Noncoding RNAs (p. 285)
  • DNA Methylation (p. 286)
  • RNA Processing and Turnover (p. 287)
  • Processing of Ribosomal and Transfer RNAs (p. 287)
  • Processing of mRNA in Eukaryotes (p. 290)
  • Splicing Mechanisms (p. 292)
  • Alternative Splicing (p. 299)
  • RNA Editing (p. 300)
  • RNA Degradation (p. 301)
  • Key Experiment: Isolation of a Eukaryotic Transcription Factor (p. 276)
  • Key Experiment: The Discovery of snRNPs (p. 294)
  • Summary and Key Terms (p. 303)
  • Questions (p. 306)
  • References and Further Reading (p. 306)
  • 8 Protein Synthesis, Processing, and Regulation (p. 309)
  • Translation of mRNA (p. 309)
  • Transfer RNAs (p. 310)
  • The Ribosome (p. 311)
  • The Organization of mRNAs and the Initiation of Translation (p. 317)
  • The Process of Translation (p. 319)
  • Regulation of Translation (p. 325)
  • Protein Folding and Processing (p. 329)
  • Chaperones and Protein Folding (p. 330)
  • Enzymes that Catalyze Protein Folding (p. 332)
  • Protein Cleavage (p. 333)
  • Glycosylation (p. 335)
  • Attachment of Lipids (p. 337)
  • Regulation of Protein Function (p. 339)
  • Regulation by Small Molecules (p. 340)
  • Protein Phosphorylation (p. 341)
  • Protein-Protein Interactions (p. 344)
  • Protein Degradation (p. 344)
  • The Ubiquitin-Proteasome Pathway (p. 344)
  • Lysosomal Proteolysis (p. 347)
  • Key Experiment: Catalytic Role of Ribosomal RNA (p. 316)
  • Molecular Medicine: Antibiotic Resistance and the Ribosome (p. 320)
  • Summary and Key Terms (p. 348)
  • Questions (p. 350)
  • References and Further Reading (p. 350)
  • Part III Cell Structure and Function
  • 9 The Nucleus (p. 355)
  • The Nuclear Envelope and Traffic between the Nucleus and the Cytoplasm (p. 355)
  • Structure of the Nuclear Envelope (p. 356)
  • The Nuclear Pore Complex (p. 361)
  • Selective Transport of Proteins to and from the Nucleus (p. 362)
  • Regulation of Nuclear Protein Import (p. 368)
  • Transport of RNAs (p. 369)
  • Internal Organization of the Nucleus (p. 371)
  • Chromosomes and Higher-Order Chromatin Structure (p. 371)
  • Sub-Compartments within the Nucleus (p. 374)
  • The Nucleolus and rRNA Processing (p. 375)
  • Ribosomal RNA Genes and the Organization of the Nucleolus (p. 376)
  • Transcription and Processing of rRNA (p. 377)
  • Ribosome Assembly (p. 379)
  • Key Experiment: Nuclear Lamina Diseases (p. 359)
  • Molecular Medicine: Identification of Nuclear Localization Signals (p. 364)
  • Summary and Key Terms (p. 380)
  • Questions (p. 382)
  • References and Further Reading (p. 382)
  • 10 Protein Sorting and Transport: The Endoplasmic Reticulum, Golgi Apparatus, and Lysosomes (p. 385)
  • The Endoplasmic Reticulum (p. 386)
  • The Endoplasmic Reticulum and Protein Secretion (p. 386)
  • Targeting Proteins to the Endoplasmic Reticulum (p. 387)
  • Insertion of Proteins into the ER Membrane (p. 393)
  • Protein Folding and Processing in the ER (p. 398)
  • Quality Control in the ER (p. 400)
  • The Smooth ER and Lipid Synthesis (p. 403)
  • Export of Proteins and Lipids from the ER (p. 406)
  • The Golgi Apparatus (p. 408)
  • Organization of the Golgi (p. 409)
  • Protein Glycosylation within the Golgi (p. 410)
  • Lipid and Polysaccharide Metabolism in the Golgi (p. 413)
  • Protein Sorting and Export from the Golgi Apparatus (p. 414)
  • The Mechanism of Vesicular Transport (p. 417)
  • Experimental Approaches to Understanding Vesicular Transport (p. 417)
  • Cargo Selection, Coat Proteins, and Vesicle Budding (p. 419)
  • Vesicle Fusion (p. 420)
  • Lysosomes (p. 424)
  • Lysosomal Acid Hydrolases (p. 424)
  • Endocytosis and Lysosome Formation (p. 424)
  • Phagocytosis and Autophagy (p. 428)
  • Key Experiment: The Signal Hypothesis (p. 390)
  • Molecular Medicine: Gaucher Disease (p. 426)
  • Summary and Key Terms (p. 431)
  • Questions (p. 431)
  • References and Further Reading (p. 431)
  • 11 Bioenergetics and Metabolism: Mitochondria, Chloroplasts, and Peroxisomes (p. 433)
  • Mitochondria (p. 434)
  • Organization and Function of Mitochondria (p. 434)
  • The Genetic System of Mitochondria (p. 435)
  • Protein Import and Mitochondrial Assembly (p. 437)
  • The Mechanism of Oxidative Phosphorylation (p. 443)
  • The Electron Transport Chain (p. 444)
  • Chemiosmotic Coupling (p. 445)
  • Transport of Metabolites across the Inner Membrane (p. 450)
  • Chloroplasts and Other Plastids (p. 451)
  • The Structure and Function of Chloroplasts (p. 451)
  • The Chloroplast Genome (p. 452)
  • Import and Sorting of Chloroplast Proteins (p. 454)
  • Other Plastids (p. 456)
  • Photosynthesis (p. 458)
  • Electron Flow through Photosystems I and II (p. 459)
  • Cyclic Electron Flow (p. 461)
  • ATP Synthesis (p. 462)
  • Peroxisomes (p. 462)
  • Functions of Peroxisomes (p. 463)
  • Peroxisome Assembly (p. 465)
  • Key Experiment: The Chemiosmotic Theory (p. 448)
  • Molecular Medicine: Diseases of Mitochondria: Leber's Hereditary Optic Neuropathy (p. 438)
  • Summary and Key Terms (p. 467)
  • Questions (p. 469)
  • References and Further Reading (p. 470)
  • 12 The Cytoskeleton and Cell Movement (p. 473)
  • Structure and Organization of Actin Filaments (p. 473)
  • Assembly and Disassembly of Actin Filaments (p. 474)
  • Organization of Actin Filaments (p. 480)
  • Association of Actin Filaments with the Plasma Membrane (p. 482)
  • Protrusions of the Cell Surface (p. 485)
  • Actin, Myosin, and Cell Movement (p. 486)
  • Muscle Contraction (p. 487)
  • Contractile Assemblies of Actin and Myosin in Nonmuscle Cells (p. 491)
  • Nonmuscle Myosins (p. 493)
  • Formation of Protrusions and Cell Movement (p. 495)
  • Intermediate Filaments (p. 497)
  • Intermediate Filament Proteins (p. 497)
  • Assembly of Intermediate Filaments (p. 498)
  • Intracellular Organization of Intermediate Filaments (p. 499)
  • Functions of Keratins and Neurofilaments: Diseases of the Skin and Nervous System (p. 502)
  • Microtubules (p. 505)
  • Structure and Dynamic Organization of Microtubules (p. 505)
  • Assembly of Microtubules (p. 507)
  • Organization of Microtubules within Cells (p. 510)
  • Microtubule Motors and Movement (p. 511)
  • Identification of Microtubule Motor Proteins (p. 511)
  • Cargo Transport and Intracellular Organization (p. 514)
  • Cilia and Flagella (p. 517)
  • Reorganization of Microtubules during Mitosis (p. 520)
  • Chromosome Movement (p. 521)
  • Key Experiment: Expression of Mutant Keratin Causes Abnormal Skin Development (p. 502)
  • Key Experiment The Isolation of Kinesin (p. 514)
  • Summary and Key Terms (p. 523)
  • Questions (p. 526)
  • References and Further Reading (p. 526)
  • 13 The Plasma Membrane (p. 529)
  • Structure of the Plasma Membrane (p. 529)
  • The Phospholipid Bilayer (p. 530)
  • Membrane Proteins (p. 532)
  • Mobility of Membrane Proteins (p. 537)
  • The Glycocalyx (p. 540)
  • Transport of Small Molecules (p. 540)
  • Passive Diffusion (p. 541)
  • Facilitated Diffusion and Carrier Proteins (p. 542)
  • Ion Channels (p. 543)
  • Active Transport Driven by ATP Hydrolysis (p. 550)
  • Active Transport Driven by Ion Gradients (p. 555)
  • Endocytosis (p. 556)
  • Phagocytosis (p. 557)
  • Receptor-Mediated Endocytosis (p. 558)
  • Protein Trafficking in Endocytosis (p. 563)
  • Key Experiment: The LDL Receptor (p. 559)
  • Molecular Medicine: Cystic Fibrosis (p. 554)
  • Summary and Key Terms (p. 566)
  • Questions (p. 567)
  • References and Further Reading (p. 567)
  • 14 Cell Walls, the Extracellular Matrix, and Cell Interactions (p. 569)
  • Cell Wall (p. 569)
  • Bacterial Cell Walls (p. 570)
  • Eukaryotic Cell Walls (p. 570)
  • The Extracellular Matrix and Cell-Matrix Interactions (p. 575)
  • Matrix Structural Proteins (p. 575)
  • Matrix Polysaccharides (p. 578)
  • Matrix Adhesion Proteins (p. 579)
  • Cell-Matrix Interactions (p. 580)
  • Cell-Cell Interactions (p. 584)
  • Adhesion Junctions (p. 584)
  • Tight Junctions (p. 588)
  • Gap Junctions (p. 589)
  • Plasmodesmata (p. 592)
  • Key Experiment: The Characterization of Integrin (p. 582)
  • Molecular Medicine: Gap Junction Diseases (p. 591)
  • Summary and Key Terms (p. 593)
  • Questions (p. 594)
  • References and Further Reading (p. 595)
  • Part IV Cell Regulation
  • 15 Cell Signaling (p. 599)
  • Signaling Molecules and Their Receptors (p. 600)
  • Modes of Cell-Cell Signaling (p. 600)
  • Steroid Hormones and the Nuclear Receptor Superfamily (p. 601)
  • Nitric Oxide and Carbon Monoxide (p. 603)
  • Neurotransmitters (p. 604)
  • Peptide Hormones and Growth Factors (p. 605)
  • Eicosanoids (p. 607)
  • Plant Hormones (p. 608)
  • Functions of Cell Surface Receptors (p. 609)
  • G Protein-Coupled Receptors (p. 610)
  • Receptor Protein-Tyrosine Kinases (p. 612)
  • Cytokine Receptors and Nonreceptor Protein-Tyrosine Kinases (p. 616)
  • Receptors Linked to Other Enzymatic Activities (p. 616)
  • Pathways of Intracellular Signal Transduction (p. 617)
  • The cAMP Pathway: Second Messengers and Protein Phosphorylation (p. 618)
  • Cyclic GMP (p. 620)
  • Phospholipids and Ca[superscript 2+] (p. 621)
  • The PI 3-Kinase/Akt and mTOR Pathways (p. 624)
  • MAP Kinase Pathways (p. 627)
  • The JAK/STAT and TGF-[beta]/Smad Pathways (p. 633)
  • NF-[kappa]B Signaling (p. 634)
  • The Hedgehog, Wnt, and Notch Pathways (p. 634)
  • Signal Transduction and the Cytoskeleton (p. 637)
  • Integrins and Signal Transduction (p. 637)
  • Regulation of the Actin Cytoskeleton (p. 638)
  • Signaling Networks (p. 640)
  • Feedback and Crosstalk (p. 640)
  • Networks of Cellular Signal Transduction (p. 641)
  • Key Experiment: The Src Protein-Tyrosine Kinase (p. 612)
  • Molecular Medicine: Cancer: Signal Transduction and the ras Oncogenes (p. 629)
  • Summary and Key Terms (p. 643)
  • Questions (p. 646)
  • References and Further Reading (p. 646)
  • 16 The Cell Cycle (p. 649)
  • The Eukaryotic Cell Cycle (p. 650)
  • Phases of the Cell Cycle (p. 650)
  • Regulation of the Cell Cycle by Cell Growth and Extracellular Signals (p. 652)
  • Cell Cycle Checkpoints (p. 654)
  • Restricting DNA Replication to Once per Cell Cycle (p. 656)
  • Regulators of Cell Cycle Progression (p. 657)
  • Protein Kinases and Cell Cycle Regulation (p. 657)
  • Families of Cyclins and Cyclin-Dependent Kinases (p. 661)
  • Growth Factors and the Regulation of G[subscript 1] Cdk's (p. 665)
  • DNA Damage Checkpoints (p. 667)
  • The Events of M Phase (p. 669)
  • Stages of Mitosis (p. 669)
  • Cdk1/Cyclin B and Progression to Metaphase (p. 672)
  • The Spindle Assembly Checkpoint and Progression to Anaphase (p. 675)
  • Cytokinesis (p. 677)
  • Meiosis and Fertilization (p. 678)
  • The Process of Meiosis (p. 678)
  • Regulation of Oocyte Meiosis (p. 681)
  • Fertilization (p. 684)
  • Key Experiment: The Discovery of MPF (p. 658)
  • Key Experiment: The Identification of Cyclin (p. 662)
  • Summary and Key Terms (p. 685)
  • Questions (p. 687)
  • References and Further Reading (p. 687)
  • 17 Cell Death and Cell Renewal (p. 689)
  • Programmed Cell Death (p. 690)
  • The Events of Apoptosis (p. 690)
  • Caspases: The Executioners of Apoptosis (p. 692)
  • Central Regulators of Apoptosis: The Bcl-2 Family (p. 695)
  • Signaling Pathways that Regulate Apoptosis (p. 698)
  • Stem Cells and the Maintenance of Adult Tissues (p. 700)
  • Proliferation of Differentiated Cells (p. 700)
  • Stem Cells (p. 703)
  • Medical Applications of Adult Stem Cells (p. 708)
  • Embryonic Stem Cells and Therapeutic Cloning (p. 709)
  • Embryonic Stem Cells (p. 710)
  • Somatic Cell Nuclear Transfer (p. 713)
  • Key Experiment: Identification of Genes Required for Programmed Cell Death (p. 694)
  • Key Experiment: Culture of Embryonic Stem Cells (p. 710)
  • Summary and Key Terms (p. 716)
  • Questions (p. 717)
  • References and Further Reading (p. 717)
  • 18 Cancer (p. 719)
  • The Development and Causes of Cancer (p. 719)
  • Types of Cancer (p. 720)
  • The Development of Cancer (p. 721)
  • Causes of Cancer (p. 723)
  • Properties of Cancer Cells (p. 724)
  • Transformation of Cells in Culture (p. 728)
  • Tumor Viruses (p. 729)
  • Hepatitis B and C Viruses (p. 729)
  • SV40 and Polyomavirus (p. 730)
  • Papillomaviruses (p. 731)
  • Adenoviruses (p. 731)
  • Herpesviruses (p. 732)
  • Retroviruses (p. 732)
  • Oncogenes (p. 733)
  • Retroviral Oncogenes (p. 734)
  • Proto-Oncogenes (p. 735)
  • Oncogenes in Human Cancer (p. 738)
  • Functions of Oncogene Products (p. 741)
  • Tumor Suppressor Genes (p. 746)
  • Identification of Tumor Suppressor Genes (p. 746)
  • Functions of Tumor Suppressor Gene Products (p. 750)
  • Roles of Oncogenes and Tumor Suppressor Genes in Tumor Development (p. 753)
  • Molecular Approaches to Cancer Treatment (p. 755)
  • Prevention and Early Detection (p. 755)
  • Molecular Diagnosis (p. 756)
  • Treatment (p. 756)
  • Key Experiment: The Discovery of Proto-Oncogenes (p. 737)
  • Molecular Medicine STI-571: Cancer Treatment Targeted against the bcr/abl Oncogene (p. 759)
  • Summary and Key Terms (p. 761)
  • Questions (p. 763)
  • References and Further Reading (p. 763)
  • Answers to Questions (p. 767)
  • Glossary (p. 779)
  • Index (p. 799)

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