Recombinant DNA : genes and genomes : a short course / James D. Watson ... [et al.]
Contributor(s): Watson, James D.Material type: Book; Format: print Publisher: New York : W.H. Freeman and Company, 2007Edition: 3rd. ed.Description: XXII, 474 p. : il. ; 28 cm.ISBN: 0716728664.Subject(s): Ácido desoxirribonucleico | Genes | Genomas
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Enhanced descriptions from Syndetics:
Recombinant DNA, Third Edition , is an essential text for undergraduate, graduate, and professional courses in Genomics, Cell and Molecular Biology, Recombinant DNA, Genetic Engineering, Human Genetics, Biotechnology, and Bioinformatics. The Third Edition of this landmark text offers an authoritative, accessible, and engaging introduction to modern, genome-centered biology from its foremost practitioners. The new edition explores core concepts in molecular biology in a contemporary inquiry-based context, building its coverage around the most relevant and exciting examples of current research and landmark experiments that redefined our understanding of DNA. As a result, students learn how working scientists make real high-impact discoveries. The first chapters provide an introduction to the fundamental concepts of genetics and genomics, an inside look at the Human Genome Project, bioinformatic and experimental techniques for large-scale genomic studies, and a survey of epigenetics and RNA interference. The final chapters cover the quest to identify disease-causing genes, the genetic basis of cancer, and DNA fingerprinting and forensics. In these chapters the authors provide examples of practical applications in human medicine, and discuss the future of human genetics and genomics projects.
This is the authoritative introduction to the concepts and techniques of recombinant DNA research and their dramatic results. The book explores core concepts in molecular biology in a contemporary inquiry-based context, building its coverage around the landmark experiments that redefined our understanding of DNA. As a result, students learn how working scientists make real high-impact discoveries. Included are chapters on applications to human diseases, cancer, and forensics.
Índice: ѵFoundations of DNA. Overview. DNA is the Primary Genetic. >From DNA to Protein. Basics of Gene Expression. Basic Tools of Recombinant DNA. Fundamental Features of Genes. Getting DNA into Cells and Organisms. Moveable Elements. Epigenetics. RNAi . Foundations of Genomics. Overview. Sequencing a Small Genome . How the Human Genome was Sequenced. Analyzing Genomes. Overview. Sequence Analysis. Genome-wide Functional Analysis. Genomic Approaches to Human Biology. Hunting Human Disease Genes. Cancer Genomics. DNA and Justice ̕
Table of contents provided by Syndetics
- Foundations of DNA
- 1 DNA Is the Primary Genetic Material
- 2 Information Flow from DNA to Protein
- 3 Control of Gene Expression
- 4 Basic Tools of Recombinant DNA
- 5 Fundamental Features of Eukaryotic Genes
- 6 A New Toolbox for Recombinant DNA
- 7 Mobile DNA Sequences in the Genome
- 8 Epigenetic Modifications of the Genome
- 9 RNA Interference Regulates the Genome
- Foundations of Genomics
- 10 Fundamentals of Whole-Genome Sequencing
- 11 How the Human Genome was Sequenced
- Analyzing Genomes
- 12 Comparing and Analyzing Genomes
- 13 From Genome Sequence to Gene Function
- Human Genomics
- 14 Finding Human Disease Genes
- 15 Understanding the Genetic Basis of Cancer
- 16 DNA Fingerprinting and Forensics
Author notes provided by SyndeticsJames Dewey Watson James D. Watson was born on April 6, 1928. Watson was an extremely industrious student and entered the University of Chicago when he was only 15. He received his Bachelor of Science degree in Zoology four years later, and went on to earn a Ph.D. in the same subject at Indiana University. He was performing research at the University of Copenhagen in Denmark, when he first learned of the biomolecular research at the Cavendish Laboratory of Cambridge University in England. Watson joined Francis Crick in this work in 1951.
At the age of 25, he and colleague Crick discovered the structure of DNA, the double helix. Watson went on to become a Senior Research Fellow in Biology at the California Institute of Technology, before returning to Cambridge in 1955. The following year he moved to Harvard University, where he became Professor of Biology, a post he held until 1976. Watson and Crick won the 1962 Nobel Laureate in Medicine for their discoveries concerning the molecular structure of nuclear acids and its significance for information transfer in living material. In 1968, Watson published his account of the DNA discovery, "The Double Helix." The book became an international best-seller.
Watson became the Director and later President of the Cold Spring Harbor Laboratory. In 1988 he served as Director of the Human Genome Project at the National Institutes of Health, a massive project to decipher the entire genetic code of the human species. Watson has received many awards and medals for his work, along with the Nobel Prize, he has also received the Presidential Medal of Freedom.
(Bowker Author Biography)