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Analogue-based drug discovery / edited by János Fischer and C. Robin Ganellin

Contributor(s): Fischer, János [] | Ganellin, C. Robin [].
Material type: materialTypeLabelBook; Format: print Publisher: Weinheim : Wiley-VCH, 2006Description: XXXI, 575 p. ; 25 cm.ISBN: 3-527-31257-9.Subject(s): Medicamentos -- Desarrollo | Química farmacéutica | Farmacología
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615/ANA (Browse shelf) Checked out PREST. LIBROS 31/01/2020 3742454178
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The first authoritative overview of past and current strategies, this resource spans all important drug classes and therapeutic fields. Includes a table of all commercially successful drug analogs and compares them in terms of chemical structure, mode of action and patentability.

Índice: Introduction GENERAL ASPECTS OF ANALOGUE-BASED DRUG DISCOVERY Analogues as a Means of Discovering New Drugs Drug Likeness and Analogue-Based Drug Discovery Privileged Structures and Analog-Based Drug Discovery SELECTED EXAMPLES FROM THE ANALOGUE-BASED DRUG DISCOVERIES Development of Anti-Ulcer H2-Receptor Histamine Antagonists Esomeprazole in the Framework of Proton-Pump Inhibitor Development The Development of a New Proton-Pump Inhibitor: The Case History of Pantoprazole Optimizing the Clinical Pharmacologic Properties of the HMG-CoA Reductase Inhibitors Optimizing Antihypertensive Therapy by Angiotensin... Etc.

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