Índice

Bibliografía

INDICE: I. HISTORY. References. II. EVOLUTIONARY ORIGIN OF MITOCHONDRIA. References. III. STRUCTURE AND MORPHOLOGY. INTEGRATION INTO THE CELL. 3.1 Structure and Morphology. 3.2 Integration into the Cell. 3.2.1 Distribution in the Cytosol. 3.2.2 Interaction with Cytoskeleton. 3.3. The dynamics of mitochondrial morpholoy. 3.3.1 Mitochondrial Shape Changes. 3.3.1.1 Fission. 3.3.1.2 Fusion. 3.3.2. Distribution during Cell Division. 3.3.3. During Cell Differentiation. 3.3.4. Turnover and Degradation. 3.3.5. Mitochondrial Alterations in Apoptosis. 3.3.6. Unsolved Problems for the Future. References. IV. BIOGENESIS OF MITOCHONDRIA. 4.1 The Mitochondrial Genome. 4.1.1. Introduction. 4.1.2. The Mitochondrial Genome in Metazoans. 4.1.3. The Mitochondrial Genome in Plants. 4.1.4. The Mitochondrial Genome in Fungi. 4.1.5. The Mitochondrial Genome in Kinetoplastid Protozoa. 4.1.6. Mitochondrial Plasmids. 4.1.6.1. Fungal senescence. 4.1.6.2. Phytopathogenicity. 4.1.6.3. Cytoplasmic male sterility (CMS). 4.2 Nuclear Genes encoding Mitochondrial Proteins. 4.2.1. Enzymes Required for Maintenance and Expression of the Mitochondrial. Genome. 4.2.2. Nucleo-mitochondrial Interactions. 4.2.2.1 Introduction.. 4.2.2.2. In Yeast, Saccharomyces cerevisiae. 4.2.2.3 Regulation of nuclear respiratory genes in mammalian cells. 4.2.2.4. Co-evolution of nuclear and mitochondrial genomes. 4.3 Replication and Maintenance of Mitochondrial DNA. 4.3.1. DNA Replication in Mammalian Mitochondria. 4.3.2. mtDNA Repair in Mammalian Mitochondria. 4.3.3. Recombination in Mammalian Mitochondria. 4.3.4. mtDNA Maintenance and Replication in other Organisms. 4.4 Transcription of Mitochondrial DNA - RNA Metabolism. 4.4.1. Transcription in Mammalian Mitochondria. 4.4.2. Transcription of mtDNA in the Yeast Saccharomyces cerevisiae. 4.4.3. Transcription of mtDNA in Plant Mitochondria. 4.4.4. Transcriptional Termination. 4.4.5. RNA Processing in Mitochondria. 4.4.6. RNA Editing in Kinetoplastid Protozoa. 4.4.7. Editing in Plant Mitochondria. 4.4.8. Control of mRNA Levels by Turnover. 4.5 Translation of mitochondrial mRNAs. 4.5.1. Introduction. 4.5.2. Codon usage and tRNA structure. 4.5.3. Mitochondrial Ribosomes. 4.5.4. Cis-acting Elements. 4.5.5. Translation factors. 4.6 Protein Import into Mitochondria. 4.6.1. Mitochondrial targeting of proteins. 4.6.2. The Protein Import Machinery of Mitochondria. 4.7 Import of tRNA into Mitochondria. 4.8 Regulated Protein Degradation in Mitochondria. References. V. MITOCHONDRIAL ELECTRON TRANSFER AND OXIDATIVE PHOSPHORYLATION. 5.1 Historical Introduction. 5.2 The Electron Transport Chain. 5.2.1. The Biochemical Components. 5.2.2 Physical Separation of the Complexes of the ETC. 5.2.2.1 Biochemical Fractionations. 5.2.2.2 Supercomplexes. 5.2.3 Introduction to Bioenergetics. 5.2.4 Complex I. 5.2.5 Complex II. 5.2.6 Complex III. 5.2.7 Complex IV. 5.2.8 The Assembly of the Electron Transport Chain Complexes. 5.3 Electron Transport in Other Organisms. 5.3.1. NA