Preparation of compounds labeled with tritium and carbon-14 / Rolf Voges, J. Richard Heys, Thomas Moenius
Contributor(s): Heys, J. Richard | Moenius, Thomas.Material type: Book; Format: print Publisher: West Sussex : John Wiley & Sons, 2009Description: XVI, 664 p. ; 26 cm.ISBN: 978-0-470-51607-2.Subject(s): Síntesis orgánica | Radiomarcado | Tritio | Carbono -- Isótopos
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Bibliografía: p. 634-637
Compounds tagged with carbon-14 and tritium are critical tools in research in biomedical sciences, discovery and development of pharmaceuticals and agrochemicals, and investigations into the nature of chemical reactions and the ways living organisms incorporate and modify biological components. Preparation of Compounds Labeled with Tritium and Carbon-14 is a comprehensive, authoritative and up-to-date discussion of the strategies for the preparation of compounds labeled with carbon-14 and tritium. It contains up-to-date synthetic strategies; basic knowledge on the preparation of labelled starting materials and essential equipment; and recommendations for the selection of appropriate labelling positions and for the appropriate use of labelled compounds - which isotope and which labelling position to use for which purpose. Topics include: Preparation of tritium-labelled compounds by chemical routes and by H/T-isotope exchange reactions The [14C]-trees: [14C]carbon dioxide; [14C]cyanide; [14C]acetylene; and [14C]cyanamide Partial degradation/restoration strategies Preparation of enantiomerically pure compounds labelled with isotopes of hydrogen or carbon Biological methods Purification strategies Safe handling and storage Analytical techniques Preparation of Compounds Labeled with Tritium and Carbon-14 is an essential guide to the specialist strategies and tactics used by chemists to prepare compounds tagged with the radioactive atoms carbon-14 and tritium.