TY  - BOOK
AU  - Copeland,Robert Allen
TI  - Evaluation of enzyme inhibitors in drug discovery: a guide for medicinal chemists and pharmacologists 
T2  - Methods of biochemical analysis
SN  - 0471686964 (cloth)
U1  - 615/.19 22
PY  - 2005///
CY  - Hoboken, N.J.
PB  - Wiley-Interscience
KW  - Enzyme inhibitors
KW  - Therapeutic use
KW  - Testing
KW  - Drugs
KW  - Design
KW  - Medicamentos
KW  - Enzimas
KW  - Biotecnología
KW  - Química farmaceútica
KW  - Structure-activity relationships
KW  - Enzyminhibitoren
KW  - gtt
KW  - Enzyme Inhibitors
KW  - therapeutic use
KW  - Drug Design
KW  - chemistry
KW  - Antienzymes
KW  - Emploi en thérapeutique
KW  - Tests
KW  - Médicaments
KW  - Conception
KW  - Relations structure-activité
N1  - Includes bibliographical references and index; Why enzymes as drug targets? -- Enzyme reaction mechanisms. -- Reversible modes of inhibitor interactions with enzymes. -- Assay considerations for compound library screening. -- Lead organization and structure-activity relationships for reversible inhibitors. -- Slow binding inhibitors. -- Tight binding inhibitors. -- Irreversible enzyme inactivators. -- Appendix 1.  Kinetics if biochemical reactions. -- Appendix 2.  Derivation of the enzyme-ligand binding isotherm equation. -- Appendix 3.  Serial dilution schemes
ER  -