TY  - BOOK
AU  - Fischer,János
AU  - Ganellin,C.Robin
TI  - Analogue-based drug discovery
SN  - 3-527-31257-9
PY  - 2006///
CY  - Weinheim
PB  - Wiley-VCH
KW  - Medicamentos
KW  - Desarrollo
KW  - Química farmacéutica
KW  - Farmacología
N1  - Índice
N2  - The first authoritative overview of past and current strategies, this resource spans all important drug classes and therapeutic fields. Includes a table of all commercially successful drug analogs and compares them in terms of chemical structure, mode of action and patentability; Índice: Introduction GENERAL ASPECTS OF ANALOGUE-BASED DRUG DISCOVERY Analogues as a Means of Discovering New Drugs Drug Likeness and Analogue-Based Drug Discovery Privileged Structures and Analog-Based Drug Discovery SELECTED EXAMPLES FROM THE ANALOGUE-BASED DRUG DISCOVERIES Development of Anti-Ulcer H2-Receptor Histamine Antagonists Esomeprazole in the Framework of Proton-Pump Inhibitor Development The Development of a New Proton-Pump Inhibitor: The Case History of Pantoprazole Optimizing the Clinical Pharmacologic Properties of the HMG-CoA Reductase Inhibitors Optimizing Antihypertensive Therapy by Angiotensin... Etc
ER  -