Mechanistic Toxicology is a timely textbook that provides an introduction to an important, but often neglected, area within the toxicological sciences. Using many examples and complementary background information, this volume gives new insights into the processes and mechanisms underlying the toxicity of chemicals, and explains how foreign compounds (drugs, environmental pollutants, industrial chemicals) exert their potentially damaging effects on cells and tissues. Ideal for use in undergraduate and graduate classes of pharma-toxicology and environmental toxicology, Mechanistic Toxicology is also a valuable reference for any other readers interested in this subject.

INDICE: Introduction. Mechanism of Organ-Selective Toxicity. Cellular Transport and Selective Accumulation of Toxic Compounds. Bioactivation of Xenobiotics to Reactive Metabolites. Oxidative Stress: Cell Injury, Signaling, and Gene Regulation. Disruption of Calcium Homeostasis. Apoptosis and Necrosis. Perturbation of Cell Proliferation and Tissue Repair. Covalent Interactions of Reactive Metabolites with Cellular Macromolecules. Immune Mechanisms. Specific Inactivation of Enzymes. Proteins.